Ketamine Infusions For Major Depression

Depression treatment can take many forms, from lifestyle changes to medications. It can take time for medications to have an effect, the side effects can be intolerable, and sometimes people become treatment resistant. This is where conventional treatments or therapies are not enough to control or manage depression. Ketamine therapy is proving to be a great tool to help provide a quick reset to decrease the need for medications or allow the medications to become effective once more.

A Common Problem

Major depression is one of the most common mental disorders in the United States. About 16 million adults in the United States had at least one major depressive episode in 2016, according to the National Institute of Mental Health.

A major depressive episode is generally considered to be a period of two weeks or longer during which there is either a depressed mood or loss of interest or pleasure, and at least four other symptoms, ranging from problems with eating, energy, concentration, and thoughts of suicide.

Major depression is more common among females than males. Those ages 18-25 are most likely to have major depression.

A New Solution

Ketamine Infusion Therapy For Major Depression

There are multiple ways to treat depression, from lifestyle changes to medications.  It can take time for medications to have an effect, the side effects can be intolerable, and sometimes people become treatment resistant. This is where conventional treatments or therapies are not enough to control or manage depression. Ketamine therapy is proving to be a great tool to help provide a quick reset to decrease the need for medications or allow the medications to become effective once more.  Studies are showing successful response rates greater than 70%. Ketamine remission median is about 18 days so it does require regular treatments. We are happy to work in conjunction with your psychiatrist or psychologist to help in any way we can.

 
We offer low dose ketamine infusions along with other IV therapies to help you get back to life with you being in control.  Most people have lasting effects and start seeing relief within days of their second ketamine infusion. Many people are experiencing profound depression or considering ending their life.  Ketamine infusions can give you an immediate lift that can be a life saver. It may be just what you need to give you the strength to get back on track.
 
If you or a loved one is experiencing Depression, consider Ketamine therapy and we will do our best to get you back to living.

Is Ketamine Treatment Right For Me?

As a first step, we will have you fill out a breif depression evaluation. This will help us know if you qualify for ketmaine infusion therapy. If you do qualify, we can start treatment immediately. We will start with a first infusion, and ketamine often acts within hours or less.

Evaluation

We have you fill out a brief depression evaluation.  If you qualify, we will get you in quickly. We want to help you as soon as possible.

Coordinated Care

We are happy to work in conjunction with your psychiatrist or psychologist to help in any way we can.

Follow Up Treatments

Ketamine remission median is about 18 days so it does require regular treatments.

What is ketamine infusion therapy (KIT) Like?

After your first treatment, you will fill out the same depression assessment post-infusion to monitor your response and so we can make adjustments to subsequent infusions as necessary to help you get your desired effect.  It may take 4-6 infusions for peak benefit. You may need maintenance infusions every so often or you may notice you are having a better response to your medications and psychotherapy. Either way, if you approve we will work closely with your personal physician, psychiatrist or psychologist to help you get the support you need.  Ketamine is not a cure; you still need to treat the whole patient, but Ketamine can be a great tool to feel better faster and have the mood to do the other things you need to stabilize your life.
 
If you qualify, we will start with a series of 3 infusions given 1 week apart.  At this time we will reassess to see if you are getting the desired response. If there has been no improvement in your mood, infusions are discontinued.  If you have shown a positive response, the series may continue based on your needs. Usually, infusions are given once or twice a week over 6 weeks. Once the initial series is complete, maintenance infusions are given as needed every 3-5 weeks.  We work with our patients so over time we can extend the length between infusions. The number of infusions will depend on symptom severity, other treatments, and your response.
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Research
Berman RM, Cappiello A, Anand A, et al: Antidepressant effects of ketamine in depressed patients. Biological psychiatry 2000; 47:351-354

Aan Het Rot M, Zarate CA, Jr., Charney DS, et al: Ketamine for depression: where do we go from here? Biological psychiatry 2012; 72:537-547

Atigari OV,Healy D: Sustained antidepressant response to ketamine. BMJ case reports 2013; 2013:

Browne CA,Lucki I: Antidepressant effects of ketamine: mechanisms underlying fast- acting novel antidepressants. Frontiers in pharmacology 2013; 4:161

Hasselmann HW: Ketamine as antidepressant? Current state and future perspectives. Current neuropharmacology 2014; 12:57-70

Ibrahim L, Diazgranados N, Franco-Chaves J, et al: Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012; 37:1526-1533

Lara DR, Bisol LW,Munari LR: Antidepressant, mood stabilizing and procognitive effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum 2013; 16:2111-2117

Murrough JW, Iosifescu DV, Chang LC, et al: Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. The American journal of psychiatry 2013; 170:1134-1142

Murrough JW, Perez AM, Pillemer S, et al: Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. Biological psychiatry 2013; 74:250-256

Niciu MJ, Luckenbaugh DA, Ionescu DF, et al: Subanesthetic dose ketamine does not induce an affective switch in three independent samples of treatment-resistant major depression. Biological psychiatry 2013; 74:e23-24

Okamoto N, Nakai T, Sakamoto K, et al: Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia. The journal of ECT 2010; 26:223-227